David Stone Lab Paper Published in the Journal of Cell Biology

mating yeast cells

Graduate students Xin Wang, Bryan Banh, Bethanie-Michelle Statler, Wei Tian, and Professor David Stone's article, "Mating yeast cells use an intrinsic polarity site to assemble a pheromone-gradient tracking machine,” was published in the November edition of the Journal of Cell Biology. The paper is highlighted in the Table of Contents carousel on the Journal of Cell Biology website.

How cells sense direction in shallow and complex chemical gradients is not well understood. Wang et al. propose a deterministic model of yeast gradient sensing in which signaling, polarity, and trafficking proteins localize to the predetermined division site before redistributing upgradient by a directed treadmill-like mechanism.