New Discovery of dual roles of engulfing cells in neuronal regeneration and debris removal by Nobuko Suzuki, Yi-Wen Hsieh, Chiou-Fen Chuang and Chieh Chang published in Nature Communications
Engulfing cells promote neuronal regeneration and remove neuronal debris through distinct biochemical functions of CED-1
It is unclear how removal of neuronal debris and initiation of neuronal regeneration following nerve injury are co-regulated. In this study, it was shown that the extracellular domain of the engulfment receptor, CED-1, functions as an adhesion molecule to promote neuronal regeneration after injury, independent of its function in phagocytosis. The work was led by a formal graduate student Hui Chiu and a current graduate student Nobuko Suzuki and carried out in the laboratory of Chieh Chang. A paper describing the research appears online in the journal Nature Communications on November 19.