PhD Dissertation: A Novel Metabolic Program Fuels Continued Anaerobic Glycolysis in the Hypoxia Tolerant Naked Mole-Rats by Vince Amoroso (Park Lab)
August 30, 2024
4:00 PM - 5:00 PM
Location
SELE 4289
Calendar
Download iCal FileJoin us Friday, August 30th at 4pm in SELE 4289 for "A Novel Metabolic Program Fuels Continued Anaerobic Glycolysis in the Hypoxia Tolerant Naked Mole-Rats" by Vince Amoroso (Park Lab)
Abstract: Survival strategies against the pathologies of low oxygen conditions that challenge the fundamentals of biological physiology are explored. Here within is described a novel redox shuttle that is utilized in the hypoxia-tolerant naked mole-rat, which utilizes a uniquely upregulated pulmonary gluconeogenic pathway to produce, from the bottom up, carbonyls that can yield ATP and pyruvate, which is capable of transporting redox potential to energy-demanding hypoxic organs. A multiomics analysis is conducted on hypoxic tissues, and several quantifications of key enzyme activities are provided. Interventions that block the transport of this redox shuttle are provided, and read-outs in terms of behavioral activity and cardiac parameters are also demonstrated. In conclusion, the naked mole-rat is shown to be host to a highly unique and novel pathway that provides for continued anaerobic glycolytic activity under hypoxia with implications for oncology, stroke, and other pathologies that witness hypoxic conditions.
Keywords: Hypoxia, Glycolysis, Gluconeogenesis, Redox, Pyruvate, Naked Mole-Rat
Date posted
Aug 29, 2024
Date updated
Aug 29, 2024