LIN Seminar: “Identifying New Druggable Targets for Fragile X Syndrome and Autism Spectrum Disorders” by Nien-Pei Tsai (UIUC)
January 16, 2025
4:00 PM - 5:00 PM
Location
SELE 4289
Calendar
Download iCal FilePlease join us January 16th at 4pm in SELE 4289 for a LIN Seminar featuring "Identifying New Druggable Targets for Fragile X Syndrome and Autism Spectrum Disorders" by Dr. Nien-Pei Tsai (UIUC)
Host: Chieh Chang
Abstract: Fragile X syndrome (FXS) is the most common form of inherited autism and cognitive impairment. FXS is caused by the absence of an RNA-binding protein called fragile X messenger ribonucleoprotein (FMRP). Because of numerous targets that are regulated by FMRP, the altered protein synthesis and behavioral defects associated with FXS are complex and involve many indirect pathways independent of RNA-binding. The failure of promising clinical trials prompts us to search for new therapeutic targets for FXS that are beyond traditional FMRP signaling pathways. In the seminar, I will describe our discoveries of two new druggable targets for FXS that act through completely different mechanisms. Our discoveries have the potential to foster future development of therapies for FXS and other autism spectrum disorders.
Date posted
Aug 23, 2024
Date updated
Dec 6, 2024