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Apr 18 2024

LIN Seminar: “From mutations to mechanisms: How neuronal cilia and extracellular vesicles signal” by Maureen Barr (Rutgers University)

April 18, 2024

4:00 PM - 5:00 PM


SELE 4289

Please join us on April 18th, 2024 at 4pm in SELE 4289 for a LIN Seminar featuring "From mutations to mechanisms: How neuronal cilia and extracellular vesicles signal" by Dr. Maureen Barr (Rutgers University)

Barr Lab

Host: Chieh Chang

Abstract: The Barr lab has a long-standing interest in using the model organism C. elegans to provide biological insight into human diseases affecting cilia. Cilia are sensory organelles and play critical roles in development and signaling. Cilia are also unique cellular locations for producing extracellular vesicles (EVs). We discovered that C. elegans ciliated sensory neurons shed EVs into the environment and that these EVs mediate inter-animal communication. We developed C. elegans as the first system to monitor EV biogenesis, targeting, and bioactivity and to define the EV proteome in a living animal. Understanding the fundamental biology of EV-based signaling in vivo is essential for elaborating their physiological and pathological functions in human health and disease.


Emily Beaufort

Date posted

Nov 10, 2023

Date updated

Mar 1, 2024