Apr 4 2019

LIN Seminar:Niemann-Pick Type C disease reveals link between lysosomal cholesterol, neuronal excitability, and synaptic plasticity By Eamonn Dickson, University of California, Davis

April 4, 2019

4:00 PM - 5:00 PM

Location

4289 SEL

Address

840 West Taylor, Chicago, IL 60607

Abstract: There is increasing evidence that the lysosome is involved in the pathogenesis of a variety of neurodegenerative disorders. Thus, mechanisms that link lysosome dysfunction to disruption of neuronal homeostasis offer opportunities to understand the molecular underpinnings of neurodegeneration and potentially identify specific therapeutic targets. I will discuss how investigating the neuropathology of a monogenetic neurodegenerative disease, Niemann-Pick Type C disease, has allowed us to determine that regulated cholesterol efflux from lysosomes controls the abundance of key phosphoinositide signaling lipids and calcium signaling proteins to tune ion channel function, neuronal firing patterns, calcium homeostasis, and synaptic plasticity. Collectively, these data will demonstrate the importance of the lysosome in shaping the functional identity of neurons in both health and disease.

Faculty Host: Stephanie Cologna

Contact

Suzanne Harrison

Date posted

Jan 4, 2019

Date updated

Mar 7, 2019