Nov 7 2019

LIN Seminar: Circadian Clocks in Seasonal Time and Neurodegenerative Disease by Ravi Allada, Northwestern University

November 7, 2019

4:00 PM - 5:00 PM

Location

4289 SEL

Address

840 West Taylor, Chicago, IL 60607

Host: Scott Shippy

Abstract: Circadian clocks evolved to coordinate behavior and physiology to our 24 h environment.  By measuring photoperiod (day length), circadian clocks can also mediate adaptive responses to different seasons.  Yet the molecular mechanisms  by which this works remains unclear.  Here we describe a novel clock component important for mediating the appropriate behavioral response to changing photoperiod.  Disrupted clocks are also a common element of neurodegenerative diseases and may contribute to their pathology.  Using a Huntington’s model, we demonstrate that the circadian clock can play a causal role in this disease and we apply genetic screening to discover novel pathways that link the clock to neurodegeneration.

Contact

Suzanne Harrison

Date posted

May 14, 2019

Date updated

Oct 31, 2019