The Laboratory of Integrative Neuroscience will presenting its Spring Symposium in Neuroscience: "Metabolic Flexibility Underlying Hibernation and Suspended Animation" on April 14 in Student Center East 605, 750 South Halsted, from 10:30am-1:30pm. This event is free and open to the public.
The symposium will feature two fantastic speakers (Kelly Drew, University of Alaska Fairbanks and Mark Roth, Fred Hutchinson Cancer Research Center) as well as LIN graduate students presenting lightning talks about their research.
Here is more detailed information about the talks.
"Will Humans Hibernate?"
Abstract: Hibernation, an adaptation for energy conservation, has a phylogenetic distribution suggesting that all mammals, even humans, share the genes and hence the capacity to hibernate. Fundamental to energy conservation is inhibition of thermogenesis. Secondarily are temperature dependent and putative temperature independent mechanisms that, in hibernation, decreases metabolic rate to 1% of basal metabolic rate. Stimulating central A1 adenosine receptors (A1AR) induces hibernation in hibernating species and inhibits thermogenesis with subsequent decrease in metabolic rate and body temperature characteristic of torpor in rat. Potential to translate thermolytic efficacy of A1AR agonists to the clinic is compromised, however, due to direct effects on the heart. Here we asked if bradycardia associated with A1AR agonist 6N-cyclohexyladenosine (CHA)-induced reduction in metabolism and body temperature could be reversed by the peripherally acting adenosine receptor antagonist 8-sulfophenyl theophyline (8-SPT). Both CHA- and cold-induced bradycardia are reversed with 8-SPT without influencing body temperature. Evidence supports the hypothesis that stimulating A1AR within the CNS can induce a hibernation-like state in non-hibernating species. Better understanding of the entire suite of autonomic nervous system control of hibernation will enhance feasibility that humans will someday hibernate.
"Adventures in Suspended Animation"
Abstract: We’ve been working on agents that alter the state of animation of small mammals. We learned that there is a set of three adjoining elements on the periodic table that have similar properties in that they all can cause reversible changes to reduce animation in animals when presented in the reduced form. These elemental reducing agents (ERAs) are likely primordial antioxidants that played a critical role to match redox chemistry with animation throughout evolution. ERAs are likely to still provide this function and, as we have recently found, can be employed to improve outcome in animal models of critical care medicine where redox chemistry and himation are inappropriately matched.