Photo of Brown, Joel

Joel Brown, PhD

Professor Emeritus

Biological Sciences

Building:

3352 SES

Address:

845 W. Taylor St.

Office Phone Voice:

(312) 996-4289

About

I am an evolutionary ecologist. I ask the question: How does natural selection acting as an optimization process determine feeding behaviors, population characteristics, and the properties of communities? My research includes the mathematical formulation and field tests of models and hypotheses based on foraging theory, consumer-resource models of species coexistence, and evolutionary game theory using the concept of evolutionary stable strategies (ESS).

To study foraging behaviors and link these behaviors to population and community level processes, I have extended Charnov's marginal value theorem of patch use, and developed the giving-up density (GUD) approach for assaying foraging costs and benefits. A foraging animal should leave a depletable food patch when the harvest rate no longer exceeds the metabolic, predation, and missed opportunity costs of foraging. When harvest rates are related to the remaining abundance of food, then the amount of food remaining in experimental food patches, the GUD, estimates the point at which the animal has balanced costs and benefits. At present, my lab, collaborators and I are using this behavioral indicator and giving-up density approach to examine species coexistence in urban wildlife including fox squirrels and grey squirrels, and the community organization of desert granivores in the Negev Desert, Israel (with Dr. Burt Kotler).

The Ecology of Fear (Brown et al. 1999, J. Mammal.) studies the behavioral, population, community and evolutionary consequences of the fear response of prey to their predators. These non-lethal or non-consumptive effects of predators on their prey can be larger than the actual direct mortality imposed by the predators. Furthermore, predators generally have their own suite of behaviors for responding to their prey’s. I develop and test models of foraging games between predators and prey including a coevolutionary study of New World and Old World rodents and snakes (with Dr. Burt Kotler) and long-running and collaborative work on snow leopards led by my former graduate student and now colleague, Dr. Som Ale.

Game theory and Maynard Smith and Price's pioneering concept of evolutionary stable strategies (ESS) provides a refreshing approach for modeling evolution by natural selection. To further the concept and its applications, Dr. Thomas Vincent and I have extended the ESS definition to parametric games (continuous vector-valued phenotypes) by developing the fitness generating function (G-function) and an associated 'ESS maximum principle'. This and others' research have discovered a range of outcomes and solutions to these evolutionary games. Solution concepts include local evolutionary maximum, unstable evolutionary maxima, stable evolutionary minima, and evolutionary Red Queens (non-equilibrium evolutionary dynamics). As an application, Dr. Mordachai Gersani and Dr. Zvika Abramsky, have used a split root technique (developed by Dr. Gersani) to test game theory models of root allocation in response to different habitats and competition. We continue to develop and test the consequences of plant foraging games (for light and nutrients) for species coexistence, root-shoot allocations, and even global climate change (with Drs. McNickle, Gonzalez-Meler and Christopher Whelan).

More recently in collaboration with Drs. Robert Gatenby, Anna Guliano, and Ms. Jessica Cunningham, we have applied evolutionary game theory to define, understand, model and develop treatment strategies for cancer and HIV. These models see cancer as the evolution of a new, asexual protist. The tumor becomes an ecosystem within which the tumor cells exhibit both ecological and evolutionary dynamics as they compete for space and resources, form associations, and speciate to fill the niches that emerge from heterogeneity within the tumor.

Selected Publications

(Complete list of publications on Google Scholar)

  1. Lloyd, M.C., A.O. Alfarouk, D. Verduzzo, M.M. Bui, R. Gillies, R.J., Ibrahim, M.E., J.S. Brown and R.A. Gatenby. 2014. Vascular measurements correlate with estrogen receptor status. BMC Cancer 14:279-286.
  2. Aktipis, C.A., A.M. Boddy, R.A. Gatenby, J.S. Brown and Carlo C. Maley. 2013. Life history tradeoffs in cancer evolution. Nature Reviews Cancer 13:883-892.
  3. Emerson, S.E. and J.S. Brown. 2013. Identifying preferred habitats of samango monkeys (Cercopithecus (nictitans) mitis erythrarchus) through patch use. Behavioural Processes 100:214-221.
  4. Orlando, P.A., R.A. Gatenby and J.S. Brown. 2013. Tumor evolution in space: The effects of competition colonization tradeoffs on tumor invasion dynamics. Frontiers in Oncology 3:180-191.
  5. Ale, S.B., J.S. Brown and A.T. Sullivan. 2013. Evolution of cooperation: Combining kin selection and reciprocal altruism into matrix games with social dilemmas. PLOS ONE 8(5):UNSP e63761.
  6. Alfarouk, K.O., M.E. Ibrahim, R.A. Gatenby and J.S. Brown. 2013. Riparian ecosystems in human cancers. Evolutionary Applications 6:46-53.
  7. McNickle, G.G. and J.S. Brown. 2012. Evolutionarily stable strategies for nutrient foraging and below-ground competition in plants. Evolutionary Ecology Research 14:667-687.
  8. McArthur, C., P. Orlando, P.B. Banks and J.S. Brown. 2012. The foraging tight rope between predation risk and plant toxins: a matter of concentration. Functional Ecology 26:74-83.yugi, J.O., J.S. Brown and C.J. Whelan. 2012. Foraging behavior and coexistence in two sunbird species in a Kenyan woodland. Biotropica 44:262-269.
  9. Cunningham, J.A., R.A. Gatenby and J.S. Brown. 2011. Evolutionary dynamics in cancer therapy.Molecular Pharmaceutics 8:2094-2100.
  10. Pintor, L.M., J.S. Brown and T.L. Vincent. 2011. Evolutionary game theory as a framework for studying biological invasions. American Naturalist 177:410-423.
  11. Emerson, S.E., J.S. Brown and J.D. Linden. 2011. Identifying Sykes’ monkeys’, Cercopithecus albogularis erythrarchus, axes of fear through patch use. Animal Behaviour 81:455-462.
  12. Kotler, B.P., J.S. Brown, S. Mukherjee, O. Berger-Tal and A. Bouskila. 2010. Moonlight avoidance in gerbils reveals a sophisticated interplay among time allocation, vigilance and state-dependent foraging.Proceedings of the Royal Society of London, Series B 277:1469-1474.
  13. Abu Baker, M.A. and J.S. Brown. 2010. Islands of fear: Effects of wooded patches on habitat suitability of the striped mouse in a South African grassland. Functional Ecology 24:1313-1322.
  14. Ale, S.B. and J.S. Brown. 2009. Prey behavior leads to predator: A case study of the Himalayan tahr and the snow leopard in Sagarmatha (Mt. Everest) National Park, Nepal. Israel Journal of Ecology & Evolution 55:315-327.
  15. Brown, J.S. and T.L. Vincent. 2008. Evolution of cooperation with shared costs and benefits. Proceedings of the Royal Society of London, Series B 275:1985-1994.

Education

PhD (ecology and evolutionary biology with minor in economics, advisor: Michael Rosenzweig), University of Arizona, Tucson, Arizona, U.S.A. 1986.

BA (zoology, advisor: William Wirtz), Pomona College, Claremont, California U.S.A. 1980.

O-levels. Marist Brother's College, Kwe Kwe, Zimbabwe, June 1976